How about Boggle, anyone? We played it as a family for hours when I was growing up. My kids love playing Scrabble, too.
Another vote for Apples to Apples--my children like to play with their cousins (junior version). And I don't remember if anyone mentioned Yahtzee Turbo --I was never a fan of the classic game but I like this version.

Boggle, Scrabble & Yahtzee can also be found as computer games & online. So can Apples to Apples--I just found it APPLES to APPLES

When you're curious, you find lots of interesting things to do. Walt Disney