Certainly there were LOTS of things learned in college (and medical school) that were completely useless. I took two years of college calculus- needless to say, I don't use any of it at all!
I've also had to learn lots of new skills on the fly. As a cardiologist, my field is very technology-oriented and changes frequently. I've had to keep up quickly.
Having said all of that, I think it would be a huge mistake not to go to college. Sure, there are a handful of Bill Gates out there who founded a Microsoft-type company without going to college. It's rare and I wouldn't count on that.
So much of the job/work world is getting along with your co-workers and boss. Producing whatever "product" you are producing. Although college is not necessarily the most efficient way to get a job, it's probably the safest and most secure.