coveln, so sorry for all that you are going through. DD4 had a recent period of intense misbehavior and defiance. It was not related to a medical condition but here is what worked for me. When she was in a calmer mood, I openly asked her what was bothering her. Then we discussed how we can address her concerns and I followed through.DD also misbehaves occasionally to get attention. In those situations, humor has helped. For example, if she pretends to be hurt and in pain, I will say something like, "oh,oh, I think someone's boo-boo needs to be tickled" etc. I also sometimes pretend that DD is a baby so that she can get all that silliness out of her system and realize that her current behavior is not consistent with her maturity.