One thing you may want to consider with AP/college sciences is the difference between the instruction and lab time available in each situation. Depending on the high school and college schedules, your DD might get 50 minutes a day of science instruction in college plus a 2-3 hour lab section a week vs. 50 min of combined instruction AND labs in a high school setting. On the other hand, the college course may be very demanding if, like Bio or Chem, it is acting as a "weed-out" course for certain majors. Best of luck with your planning!