From experience with my 2e son...his first IQ test had full scale IQ as 91 and then 3 years later (after ABA, etc. therapies) was 148. So I say, yes 2e-ness does affect IQ! But the psychologist wrote on the first test the standard statement saying something like "this is a correct and true demonstration of IQ and will expect to vary by 3 points," or whatever they put at the end of the test. But I haven't heard of anyone else who has had such a dramatic difference. Who knows?!
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Hi Nan,
We have that in my family. My older brother (whom we now recognize as slightly on the autism spectrum) was tested several times during childhood (maybe 4 times over a dozen years) and his score went from totally average to 140 plus.

My oldest son was tested at age 5 and given a diagnosis of mild MR (on top of his earlier autism diagnosis), at UC SF Langley Porter and he is now preparing for college (interested in history and political science). My son beats me at chess too, regularly.

OTOH my younger brother and I both scored very highly on IQ tests even as young kids, but we did not have the 2e issues my older brother and oldest son have. I don't think there is any magic to these tests which allows them to measure "potential" or "ability" perfectly. The scores clearly have some value but IMO they are more of a snapshot of current functioning and they are not as reliable as we would like. (Maybe I should say, for many/most people they may predict quite a lot but certainly for kids anywhere on the autism spectrum, in my personal experience these tests are not too reliable).