My opinions on the SSRI and SNRI classes mirror apm's.
My terminal degree was obtained in neuroscience, specifically on the neurotransmitter systems of the midbrain-- and HELL yes, to what apm notes about the relative blind spot in clinicians wrt what researchers in this field
know about those meds-- and that it
has been known for a long, long time.
There isn't a way to "trial" them. If you take them, you do risk permanent epigenetic impact on that biogenic amine neurotransmitter system. Sorry, but that is so.
I, too, do not mean to make light of the difficulty of medicating using one of those drugs (either in the stimulant class or in the SSRI/SNRI, or MAOI classes), but this is something that was observed in rodent models by people I know personally. The changes induced by use of drugs which modulated reuptake of biogenic amine neurotransmitters lasted longitudinally
for the life of the animal.Clinicians really don't seem to have any idea-- heck, most pharmacologists I've known didn't. It's worrisome as a thing among
all psychotropics, if you want my opinion (I know that you didn't ask-- I'm offering
).
Other things which have a great track record with anxiety include non-medication therapeutic interventions like EDMR and CBT, and more specific desensitization strategies.
I did PM you.
