Well, for elementary, yes-- reasonably happy story.
My DD is 2e and probably PG (she's now just polished off her second year as an honors high school student, after which she capped that by turning 13). I'd say that it STRONGLY depends upon the nature of the second exceptionality.
Most educators assume that 2e must mean GT/LD. That is clearly not so. My DD has a chronic hidden physical disability, and the reason we didn't send her to kindy in our (good) local school is that: a) she was already reading at at least a 3rd-7th grade level at barely 5yo, and more crucially, b) we were afraid that they would kill her. (Not gilding the lily there, and sorry if that offends, but it's the unvarnished truth.)
So. We homeschooled her. Well, more like child-led eclectic play and a little bit of Montessori/Charlotte Mason-esque directed learning. For a year.
Then, we were a bit horrified because she was accelerating her pace, and the gaps that had been obvious areas of asynchrony prior to that year were... um... developing into freakishly wide gaps and widening by the day. Her personality made her mulishly stubborn about working in: a) areas of relative weakness... like writing, and/or b) using non-preferred methods of learning anything.
We were also way out of our depth in terms of making sure that we weren't missing huge chunks of standard K-12 curriculum, since at this point we still thought that we'd be putting DD back into a regular classroom when she was "older." We thought that when she was about 11, she could probably be a little more proactive and it would be safer for her... but what we didn't (at the time) know was that she'd be entering high school work before then.
Enter a local virtual charter school, which we felt would help us to make sure that we didn't ignore gaps, and would provide DD with an external authority asking for her to work on less preferred areas (like writing).
We've been with Connections Academy since then. Now, it's far from perfect, and I'd be lying if I said that the way THEY (meaning the administration) think it 'works' is the way that it REALLY works for HG+ kids, but it fits better than a lot of things do, and it's pretty darned flexible through 8th grade.
It's a lot easier to deal with exceptionalities that result in special physical or emotional needs in this model.
