As long as you have a safe place for her to be when she can't be with a parent, this can work, but it requires a fair amount of organization. Instruction can happen at any time of day that works for your family. We homeschooled with both parents working overlapping shifts for a little more than a year when my son was younger. Finding care for a school-aged child for a few hours during the usual school day was our biggest challenge. Did you have any particular questions or concerns?