My husband chose his college major by reading the list of majors and selecting the one that sounded the hardest.
He loves his mathy-computery career and has been extremely successful at it. He needs to learn new things all the time, though, or he gets bored. Luckily, his field offers a lot of newness all the time.
I have always been a humanities generalist at heart, a serial monogamist of sorts in terms of my interests. I get passionate about something for a few years and learn everything there is to know about it, but then I burn out and move on to another passion. Writing novels has been a good fit for me because I can immerse myself in one world, write the book, and then move on to another world. It took me a good long while to figure that out, though!
I think it's good to play to your strengths, but more in terms of approach to learning than in terms of subject matter.
