I think very similarly to Platypus101 - school is an artificial construct. We are trying to teach to one type of student, which is an average that doesn't really exist in real life- it just hopefully works for the majority of kids.
I tend to think of my children as wired tighter than NT kids, and so all sorts of stuff comes with that. I tend to think in terms of "is their giftedness working for them or against them" rather than 2e specifically. For the kids where their brain configurations are working very efficiently in a particular way, they may be better adapted to the artificial constructs of modern society. For other gifted kids, their brains may measure similarly on an iq scale, but might be better adapted for a different type of developmental model in which adhd or other things we consider to be deficits are actually assets.