That is a tough call- I think it would vary depending on the class/teacher for us, but one can't always know that specific info during scheduling (ie, if two teachers teach the same class in different sections).
Personally, I think I would go for the challenge, but that is easy for me to say as my DD is not 2E, and I don't have personal experience with that. I will also say that our counseling department stresses to students and parents that "colleges prefer to see you get a B in the most challenging class you can handle, rather than an A in an easier class." I have no idea if this is true, but it is repeated advice here, and consequently DD has observed lots of kids in her classes getting 60s and 70s on tests and other assignments (where she earns top marks without much effort). These same kids are being scheduled into honors level classes for next year as well (I assume they are using the parental override, which allows one to enroll in higher level classes without having earned the necessary grades in the prerequisite classes).
As I said, this blanket advice seems kind of crazy, but lots of kids here seem to be following it. Not sure if that helps or not😀.