I think AP Bio might be tough without a prior Bio class and some Chem. I guess I don't know what middle school Bio would be - would that be equivalent to one year of a HS Bio course?

Our HS requires Honor Bio and Honors Chem before AP Bio. Typically students take AP Bio senior year because you must take Physics in 11th (and must take Chem in 10th). Middle kid was recommended by her 9th grade Bio teacher for AP Bio and she took it in 10th. However, the school insisted on Chem prior to or concurrent with AP Bio, so she took Chem in the summer before 10th (takes two foreign languages, couldn't fit two sciences).

She thought the Chem did help in some areas of AP Bio. Also, a full year of HS Bio helped a lot. It may just be too much catching up to HS kids who have that year of HS Bio and HS Chem.

It is great that your school is willing to accelerate though. Even after she aced her summer Chem course at a rigorous private school, our school made her take the Honors Chem final, would not provide her the HS textbook or final exam review packet, and told her that is was all MC (it was not). Told her she had to pass with an 80%. She got a 90%, then they insisted she do a lab because they weren't really sure if she understood the material...your school sounds a lot better.