Yes! The worst I remember is a Thanksgiving party last year. My son, not yet 2, spontaneously started talking about gravity with Friend A. Friend A responded positively and relayed his conversation with DS to me and Friend B (who has two intelligent children and is brilliant engineer, himself). Friend B said with a sneer, "Wow, I don't think either of my kids even knows what gravity is. Does DS know how to take the second derivative of the gravity field yet? I bet you have him into calculus."
I think Friend B was taken aback and didn't respond too charitably. I was surprised because I always ask after his children and get excited for their accomplishments. They're genuinely smart, nice people. He's since moderated his tone, but I still have the sense that he is implicitly comparing his children unfavorably to DS. Ugh!
DH and I had DS earlier than most of our social group. The childless couples and unmarried folks generally just treat DS like a mini adult and include him in whatever is going on. These people, by and large, ask after him specifically and seem excited at his interests. I answer honestly, but I don't go on at length. The rest of our friends with children have babies younger than DS. They see him and comment, "Wow! I'm can't believe my baby will be doing that in [insert X time]." To that I keep my mouth shut.