Oh my.
Although I'm no Felix Unger, I do like the kids' rooms to be reasonably neat & tidy. Basically, everything off the floor and off the bed... and put away properly.
Where I start to lose it, though, is when a child accumulates buckets of poo, which are essentially the result of a lazy clean-up effort. Finding one of these containers filled with a jumbled mess of clothing, books, toys, etc. just drives me to distraction.
My solution? A few days visiting the grandparents for both kids. I stay home and get out the bull-dozer.
To be somewhat fair, however, I will toss everything into a large "Purgatory Box" which will be held for a month or so. If the child can name a specific missing thing, I will pull it out. Otherwise, the box goes to the thrift store.
Anytime I find myself losing my resolve, I just watch an episode or two of Extreme Hoarding on Netflix. Never fails to get me all fired up again.