Mozart's Magic Flute - my son started playing this when he was four or five but it really can appeal to any age. It has a tale about young Mozart and there are many activities that require isolating instruments by sound or identifying tunes that are "warped". Really develops and enhances music "listening" skills and also of course show instruments and their names etc. I liked it because it required a different thought process than many games. It was aural and not visual. It was hard to find i any stores though and I ended up ordering it online.
Zoo Tycoon sounds neat. I imagine my little "animals" would relish releasing rampaging elephants and wild tigers on hapless zoo goers as well!
