Well, as an older parent of 4 twice exceptional kids (13b, 15b, 17g, 19g) I have to say I would only have them in pairs. It is much easier to throw things their way and have them figure out what to do with it together, than have me run over there and give praise and suggest ideas.
I did this with my first and third, and I know if I were to get pregnant now, and I have a second on the way a year or so afterward. From our experience, it is much less exhausting and the blessings of their relationships toward each other are endless.