Some districts around here let a kid go directly into the AP science course, but our district makes the kid take the honors course first (exception - this year they changed the stance on Physics since the AP Physics tests changed). So my current 11th grader took Honors Bio in 9th, Chemistry in the summer before 10th, AP Bio in 10th and now AP Physics in 11th. The school insists that you take Bio in 9th, Chem in 10th and Physics in 11th (all with lab) - that's why she took Chem over the summer (couldn't fit in two sciences plus her two foreign languages).
Take a look at the percentages of 5s in various AP exams, and there is a wide range. Also interesting to note that when some AP exams have changed, rates of 5s have changed (Bio went from 20% 5s to single digit 5s - 6.5% this year). Not sure what it means.
And 4s and 5s can help with credit in college. Eldest entered school with 24 credits from APs. Would be nice if she would finish in three years, but she decided to double major instead.