Movies -
- Akeelah and the Bee (2006),
- Gifted Hands (2009), with Cuba Gooding Jr portraying the story of world-renowned pediatric neurosurgeon, Dr. Ben Carson,
- The Pursuit of Happyness (2007), with Will Smith and his son portraying the story of Chris Gardner raising his son while overcoming many obstacles,
- The Blind Side (2009), inspired by the story of Michael Oher, is a story of struggle and success... and the interplay between talent and opportunity.
- 42 (2013), the story of baseball legend Jackie Robinson.

Books -
- Amazing Grace by Mary Hoffman, illustrated by Caroline Binch
- There are many lists and books featuring Black and African American founders, heroes, inventors, and role models, easily found online with a web search.
- Also possibly of interest: a post to a similar question can be found here.