Definately. My oldest is 2E with aspergers. My youngest twin my eventually be diagnosed 2E, she has cerebral palsy. If you want to get technical my older twin is 2E in that she is gifted and has cerebral palsy as well. The difference being that after four years and thousands of dollars of private therapy you can't tell anymore without really paying attention to her motor planning. They think my oldest son might be GT, he just started talking this last year and is potting training as we speak, he's 4.2 years old.
www.twicegifted.net has an extensive list of resources for 2E.
