I'm with Val on this one. No matter how intelligent and mature our children are, there are often going to be things where they are very much their age. Physiology has its own timetable.
For example, my DD13 just marked herself as behind age norms, nevermind her grade peers now that she's grade-skipped, when she said that she remains convinced that boys have cooties. Her cohort are spending time talking about boys and who likes who, and she's bored by the whole thing. Given that information at this point in time, it's easy to project forward and imagine that the sexual atmosphere that pervades most college dorms would not be a suitable environment for her four years hence.
I'm not sure why a 16yo should be so miserable going to college while still living at home. Lots of much older kids do it.
