Sanne, that's is what we currently do. Different doses depending on if it is a school day or not. We give him the long acting in the morning right before breakfast. It takes about 45mins - 1hr to start seeing some affects of the medication. I wish the onset time would be shorter because ds is very difficult to handle in the mornings when not medicated. Example, he has a hard time getting dressed, using the lavatory, feeding himself, and even getting into the car. Morning routines are especially hard. His teachers also notice the first hour or so in the morning he is still hyper/inattentive. At lunch he basically eats nothing at all, and he is pretty resistant to any food until evening when his medication has worn off. Night time he starts getting rowdy again but we start winding down for the night so it's not as bad as morning. The weekends we usually give him a short acting pill because he has music lessons etc. and then by lunch he has a bigger appetite. However, ds is very hard to handle when not medicated at all, so sometimes we do struggle with the "give him medication and have him not eat but keep our sanity or don't give him medication and he does eat, but our frustration levels grow."