In general, I view the key element to disorder-vs-diversity as being pathology, by which I mean, the extent to which the profile interferes with major life functions (including the subjective happiness and well-being of the individual concerned). If there is something about the profile which impairs that person's capacity to live a full and satisfying life without significant support, then I think we are entering the realm of pathology.
This matches my own experiences very well, and it's similar to my own working definition. Well put.
