Ultra, I hope you will call your DD's professional (the person who dxed the depression?) and consult them.

I find it likely that if she already has the depression DX, she's casting around for why she feels sad, and her uniqueness in being gifted is just the thing she's found to blame-- it may not be any kind of rational cause/effect. Depressed people often seek to think out reasons for why they (biochemically) feel lousy.

To me, the solution for this and the anxiety you've been talking about on other threads is to treat the depression as thoroughly as you can at this stage; if she were my kid I'd probably explore the possibilities of meds (for relief) and cognitive-behavior therapy (for long-term skill-building and resilience).

DeeDee