Thank you everyone for your empathy and feedback. I will defiantly encourage S to read all of the suggestions, as I will myself. The link to the Existential Dpression article sounds promising as he has had a kind of loss. After being mostly miserable and lonely for all of his school years, he went to a college which valued his quirkiness, for lack of a better term. He misses being there desperately and is having a hard time adjusting to the new normal of med school. My hope is that he can accept his own gifted ness so he will be comfortable with himself and that will attract other people.