I see too many people doing jobs that they dislike because they didn't know what they wanted to be when they grew up or they changed their minds later on after they realized what the career path was actually all about (this even includes some doctor friends I have). Yet they can't change the course of their life (or at least they feel they can't) because they have too much invested and are living out their parents dream for their future, not their own. They had no passion for the profession that they picked, they just knew that they could master it.
It could be worse.
I have neither passion nor mastery of my profession.
