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The depression was said to be resulting from social isolation due to the social awkwardness. Since he is making progress socially, his mood is improving, he is more resilient, especially now we are back in the habit of making sure he gets a LOT of exercise. Still sort of holding our breath on this, as you might imagine.
Did her dr. suggest a link between learning social skills and improved mood for her son?

Your situation and my friend's sound similar in some ways, chris1234. Thanks for sharing.

My friend says the doctor believes her ds6 may be depressed because he is starting to notice he is different. My friend says she knows her ds is aware that he is behind in some motor skills and is not as good in sports as others. He also seems to want to make friends but is not really sure how to go about doing so. My friend is really hoping the social skills class will help.

The doctor did indicate she thought the depression would improve if he made some positive strides in other areas.