Adrian Monk, the main character of the award-winning, vintage comedic detective series Monk (2002-2009), is depicted as intellectually gifted, being highly observant and making multiple connections among the many items he observes and the tiny details he recalls. He may also be described as 2e, suffering stress-related OCD.

Monk's assistant, Sharona, provides consistent understanding, support, and behavioral guidance to keep him on track.